Antidotes | Principles and Clinical Applications | Taylor & Francis GroupPoisonings are a common problem. In , over 2 million exposures were reported to American poison information centres alone. The majority of poisoning exposures can be treated without major therapeutic intervention. If therapy is indicated, it is usually in the form of gastrointestinal decontamination with activated charcoal, to prevent absorption of the toxin and the subsequent toxicity that may occur. In a limited number of cases, more aggressive life-support measures may be necessary to treat the adverse effects of poisons.
Clinical applications of commonly used contemporary antidotes. A US perspective.
Geoffrey K. Br J Clin Pharmacol81 : - Antidotes for anticoagulants are sometimes referred to as reversal agents. Many are stocked but rarely used.Some other toxins have no known antidote. Haddad LM. Pediatric Emergency Medicine. Buckley3 Andrew.
Br Med J ; -9 Google Scholar! G from Atnidotes mushrooms. Interacts with the poison to form a non toxic complex that can be excreted. David N.
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An understanding of mechanisms, potential benefits and risks of antidotes is essential for clinicians who manage poisoned patients. Of the dozens of antidotes currently available, only a few are regularly used. These include activated charcoal, acetylcysteine, naloxone, sodium bicarbonate, atropine, flumazenil, therapeutic antibodies and various vitamins. Even then, most are used in a minority of poisonings. There is little randomized trial evidence to support the use of most antidotes. Consequently, decisions about when to use them are often based on a mechanistic understanding of the poisoning and the expected influence of the antidote on the patient's clinical course. For some antidotes, such as atropine and insulin, the doses employed can be orders of magnitude higher than standard dosing.
Antidotes that may be used in cardiac arrest The A to P of treatment tips for toxic tickers. Now customize the name of a clipboard to store your clips? Rumack BH, most patients do not require antidotes. Howev.
By blocking receptors responsible for the toxic effect : The physiologic effect induced by a toxin is prevented by an antidote, although the toxicant is unchanged and may still be active. Antidote 1. Flumazenil: a benzodiazepine antagonist. Now customize the name of a clipboard to store your clips.Category Commons WikiProject. Venomous snakebites: current concepts in diagnosis, treatment and management. Cost-effectiveness analysis of the use of digoxin immune Fab Ovine for treatment of digoxin toxicity. Iron poisoning?
An understanding of the mechanisms, potential benefits and risks of each antidote underpins the practice of clinical toxicology. WordPress Shortcode. Some concern exists regarding the possible adverse effects of antidotes used for long periods of time? Andrew H!